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Methods for Obtaining and Analyzing Unattended Polysomnography Data for a Multicenter Study.
ABSTRACT
Summary: This paper reviews the data collection, processing, and analysis approaches developed to
obtain comprehensive unattended polysomnographic data for the Sleep Heart Health Study, a multicenter study of
the cardiovascular consequences of sleep-disordered breathing. Protocols were developed and implemented to
standardize in-home data collection procedures and to perform centralized sleep scoring. Of 7027 studies
performed on 6697 participants, 5534 studies were determined to be technically acceptable (failure rate 5.3%).
Quality grades varied over time, reflecting the influences of variable technician experience, and equipment aging and
modifications. Eighty-seven percent of studies were judged to be of "good" quality or better, and 75%
were judged to be of sufficient quality to provide reliable sleep staging and arousal data. Poor submental EMG
(electromyogram) accounted for the largest proportion of poor signal grades (9% of studies had <2 hours artifact
free EMG signal). These data suggest that with rigorous training and clear protocols for data collection and
processing, good-quality multichannel polysomnography data can be obtained for a majority of unattended studies performed
in a research setting. Data most susceptible to poor signal quality are sleep staging and arousal data that require
clear EEG (electroencephalograph) and EMG signals.
Keywords: Polysomnography; epidemiology; sleep apnea