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Foscarnet-Ganciclovir
CMV Retinitis Trial (FGCRT):
Head to head comparison of foscarnet and
ganciclovir. Showed similar
efficacy for the two drugs in
controlling retinitis and a survival
advantage for foscarnet. Completed
1991.
Primary
results: New Engl J Med 326:213-220, 1992.
CMV
Retinitis Retreatment Trial (CRRT):
Test of combination therapy with
foscarnet and ganciclovir for recurrent
CMV. Showed that combination
therapy was more effective than
monotherapy. Completed 1993.
Primary
results: Arch Ophthalmol 114:23-33, 1996.
HPMPC
Peripheral CMV Retinitis Trial (HPCRT):
Trial of HPMPC (cidofovir) for newly
diagnosed patients. Showed that
Cidofovir was effective for the control
of retinitis. Contributed to FDA
approval of cidofovir. Completed
1996.
Primary
results: Ann Int Med 126:264-274, 1997.
Monoclonal
Antibody CMV Retinitis Trial (MACRT):
Trial of adjuvant therapy with MSL
109. Showed no difference between
treatment and placebo groups.
Completed 1996.
Primary
results: Arch Ophthalmol 115:1528-1536, 1997.
Ganciclovir
Cidofovir CMV Retinitis Trial (GCCRT):
Comparison of highly active local
therapy (ganciclovir implant) versus
systemic therapy (IV regimens) for
treatment of newly diagnosed or relapsed
CMV retinitis. Showed no difference
between the groups for control of
retinitis, Completed 2000.
Primary
results: Arch Ophthalmol 131:4507-467, 2001.
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